ECE 454/554 Topics in Bioelectrics (elective) - Fall 2009

Department of Electrical and Computer Engineering

- PRELIMINARY SYLLABUS -

Meeting Time and Location: KAUF 213, MW 3:00 – 4:15 pm

Prerequisites/Corequisites: MATH 212 or equivalent, PHYS232 or equivalent

Course description: A one-semster course covering the electrical properties of cells and tissues as well as the use of electricity and magnetism in the diagnosis and treatment of disease. Typical topics to be covered include Electrocardiography, cardiac pacing, defibrillation, electrotherapy, electroporation, electrotherapy in wound healing. In addition, ultrashort electrical pulses for intracellular manipulation and the application of plasmas to biological systems will be covered.

Required Texts: J. Malmivuo and R. Plonsey, Bioelectromagnetism: Principles and Applications of Bioelectric and Biomagnetic Fields, Oxford University Press, New York, NY 1995,

free online-edition: www.bem.fi/book/

Recommended References:

Instructors: Juergen F. Kolb

jkolb@odu.edu, 757-683-2414 (off-campus), 757-683-4493 (campus),

office hours: MW 9-3 (231F Kaufman Hall)

Grading Policy: ECE454: 3 on par tests (including final)

ECE 545: 3 on par tests (75%), 1 term paper (25%)

Topics:
Period		Topic
1	Aug 31	Electrical Properties of Cells, Tissues, Organs – Overview, Introduction and History: Phenomena and Mechanisms, Diagnostic and Therapeutic Applications
2	Sep 02	Biological and Engineering Fundamentals: Morphology and Physiology of Cells, Biological Membranes, Tissues and Organs, Excitable and Non-Excitable Cells
-	Sep 07	LABOR DAY HOLIDAY
3	Sep 09	Biological and Engineering Fundamentals: Electric Circuits and Signals; Circuit Representation of Cells; Electrically Small vs Large Cells
4	Sep 14	Bulk Dielectric Characteristic of Cells and Tissues: Permittivity, Conductivity; Dielectric Spectroscopy, Electrophoresis, Applications for Cancer Diagnostics
5	Sep 16	Electrical Properties of Cell Membranes: Resting Potential, Nemst Equation, Ion Flow (Channels, Gates, Pumps), Goldman-Hodgkin-Katz Equation
6	Sep 21	Active Behavior of Cell Membranes: Action Potential, Nerve Conduction, Hodgkin-Huxley Membrane Model, Experimental Approaches: Patch-Clamp
7	Sep 23	Modeling of Electric Cell Characteristics: Equivalent Circuit Models, Electronic Modeling of Excitable Tissue (Lewis Model)
8	Sep 28	Electronic Modeling of Cell Membranes: Axon Cable Models, Modeling Approaches: Distributed Circuit Models, Molecular Dynamics Simulations
9	Sep 30	TEST #1
10	Oct 05	Functional Electric Stimulation: Electrotherapy of Muscles and Nerve Fibers
11	Oct 07	Electrotherapy in Wound Healing
-	Oct 12	FALL HOLIDAYS
12	Oct 14	Anatomy and Physiology of the Heart
13	Oct 19	Electrical Activity and Activation of the Heart
14	Oct 21	Theoretical Methods of Analyzing Volume Sources, forward/inverse problem, Miller-Geselowitz Model, Einthoven triangle, Gabor-Nelson Theorem
15	Oct 26	The Normal and Abnormal EKG
16	Oct 28	Cardiac Pacing, Cardiac Defibrillation
17	Nov 02	Electrical Accidents and Injuries
18	Nov 04	TEST #2
19	Nov 09	Electrically Induced Interactions with Cells and Tissues: Plasma, Microwaves/RF-Stimulation, ‘Long’ vs ‘Short’ Pulsed Electric Fields, Magnetic Stimulation, ELF-Effects
20	Nov 11	Health Effects from Cell Phones and other Radiofrequency Transmitters
21	Nov 16	Plasma-Cell Interactions and Applications
22	Nov 18	Plasmamedicine
23	Nov 23	‘Long” Pulsed Electric Fields – Electroporation
24	Nov 25	THANKSGIVING HOLIDAYS
25	Nov 30	Electroporation: Applications for ‘Drug Delivery, Gene Therapy
26	Dec 02	Nanosecond Pulsed Electric Fields – Intracellular Electroeffects
27	Dec 07	Nanosecond Pulsed Electric Fields: Cancer Therapies, Wound Healing
28	Dec 09	Picosecond High Voltage Pulses for Therapy and Diagnostic
29		TEST #3 (Final)